Sweeteners Discovery, Molecular Design, and Chemoreception
by Walters, D. Eric; DuBois, Grant E.; Orthoefer, Frank T.Format: Hardcover
Pub. Date: 1991-05-05
Publisher(s): American Chemical Society
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Summary
At one time, sweetener discovery was largely a matter of chance. Now it is possible to design and synthesize new sweet compounds based on the studies of structure-taste relationships, computer modeling, and biochemical chemoreception mechanisms. This new volume presents the latest results ofsuch studies and defines the status of methodology to design sweetners, the evaluation of sweeteners' sensory properties, the mechanism of action of sweeteners, and legislation for the regulation of sweeteners. In addition, this volume presents, for the first time outside of the patent literature,discussions of three major new structural classes of sweeteners: arylurea dipeptides, guanidineacetic acids, and substituted b-amino acid.
Table of Contents
| The Rational Discovery of Sweeteners | |
| New Highly Sweet Compounds from Natural Sources | |
| Sweet Proteins: Biochemical Studies | |
| Sweet Peptides and Proteins: Synthetic Studies | |
| Development and Uses of Alitame: A Novel Dipeptide Amide Sweetener | |
| Sucralose: How to Make Sugar Sweeter | |
| Design of Sweeneners: A Rational Approach | |
| Tetrazoles as Carboxylic Acid Surrogates: High-Potency Sweeteners | |
| High Potency Sweeteners Derived from b-Amino Acids | |
| Molecular Basis of Taste: Stereoisomeric Approach | |
| Structure-Activity Relationship of Sweet Molecules | |
| Molecular Mechanics of Cyclopropane Peptide Analogs of Aspartame: Implicationsfor Three-Dimensional Requirements of the Sweet Taste Receptor | |
| Shape of Sweet Receptors Studied by Computer Modeling | |
| Electrostatic Recognition Patterns of Sweet-Tasting Compounds | |
| Why Does a Sweetener Taste Sweet?: A New Model | |
| Three-Dimensional Model for the Sweet Taste Receptor: Development and Use | |
| Sweet Taste Transduction: A Molecular-Biological Analysis | |
| Mechanisms of Sweet Taste Transduction | |
| Phenoxyalkanoic Acid Sweetness Inhibitors | |
| Concentration-Response Relationships of Sweeteners: A Systematic Study | |
| Time-Intensity Profiles of Dipeptide Sweeteners | |
| Electrophysiological Evaluation of Sweeteners | |
| Novel Sweeteners: Regulatory Issues and Implications | |
| The Future of Synthetic Sweeteners | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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