Sepsis and Non-infectious Systemic Inflammation From Biology to Critical Care

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Edition: 1st
Format: Hardcover
Pub. Date: 2008-11-24
Publisher(s): Wiley-Blackwell
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Summary

Providing definitions, clinical features and epidemiology, Sepsis and Non-infectious Systemic Inflammation adopts a comprehensive approach, describing in detail the various physiological systems involved. As such, this unique handbook and reference work is the first to combine sepsis and non-infectious SIRS, reviewing both the biological and medical aspects of these two important syndromes. The whole is rounded off with a discussion of past, present and future therapies.

Author Biography

Jean-Marc Cavaillon is head of the department Infection and Epidemiology at Institut Pasteur in Paris, France. Having obtained his academic degrees from Paris University, he spent most of his career working at Institut Pasteur. There, he has been director of the General Immunolgy course, scientific director of Euroconferences, and is head of the research unit Cytokines and Inflammation. Cavaillon has authored 117 scientific publications, 92 reviews and chapters, and a book on cytokines. He has been president of the International Endotoxin Society. He is member of the editorial boards of numerous journals.

Christophe Adrie is physician in Saint-Denis, France and has got his degree (MD, PhD) from Paris University. His main topics are systemic inflammation in sepsis and non-septic ones with a particular interest to the post-resuscitation phase after cardiac arrest successfully resuscitated on both clinical and biological aspects. He is also member of the Outcomerea database (epidemiological studies) and Family-rea group which studies the relationship between family and medical staff. He has authored 41 scientific publications, 9 reviews and 3 book chapters. He is a member of the French Society of Critical Care Medicine.

Table of Contents

Clinical Aspects of Sepsis and Sirs
Definition of Sepsis and Non-Infectious SIRS
Epidemiology of Sepsis and Non-Infectious SIRS
Similarities of the Clinical Aspects of Sepsis and Non-Infectious SIRS
Organ Dysfunction during Severe Sepsis and Septic-like Syndromes: Epidemiology, Classification and Mechanisms
Pathogens
Pathogens in Sepsis : Gram-Negative Bacterial PAMPs and PRRs
Pathogens in Sepsis : Gram-Positive Bacterial PAMPs, PRRs and Superantigens
Pathogens in Sepsis : Fungi and Parasites
Physopathology of Sepsis and Sirs
Inflammatory Mediators
Apoptosis: A Potential Therapeutic Target in Sepsis and Non-Infectious Systemic Inflammation
Role of Endothelium
Coagulation
Epithelial Barrier Dysfunction as a Mechanism in the Pathogenesis of Multiple Organ Dysfunction
Neural Regulation of Cytokines
Genetic Polymorphisms and other Parameters that affect Predisposal to Infection and Outcome
Altered Immune Status and Leukocytes Reprogramming
Experimental Models and Therapies
Experimental Models of Sepsis and Non-Infectious SIRS
Past, Present and Future of Therapies for Sepsis and Non-Infectious Systemic Inflammation
Table of Contents provided by Publisher. All Rights Reserved.

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