Summary
This authoritative resource comprehensively covers the use of drug therapies in the treatment of mood disorders and schizophrenia. It is divided into three sections. The first two, Schizophrenia and Depression and Mania give detailed accounts of specific drug therapies, whilst the third section, Key Issues in Clinical Psychopharmacology covers a variety of current topics such as considerations for young, old and pregnant patients, substance misuse and pharmacoeconomics. The inclusion of the most up-to-date knowledge, best practices, and clinical pearls from internationally renowned contributors ensure that this is a critical resource for clinicians prescribing for their patients.
Author Biography
Dr Ruth Allen MBBS MRCPsych: Department of Psychiatry, Royal Free Hospital, London, UK. Dr Daniel Andrews MRCPsych BSc: Honorary Lecturer in Psychiatry, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK. Professor A. George Awad MB BCh PhD FRCP(C): Professor Emeritus, University of Toronto; Chief of Psychiatry, Department of Psychiatry, Humber River Regional Hospital, Toronto, Canada. Professor Thomas R.E. Barnes MD FRCPsych: Professor of Clinical Psychiatry, Department of Psychiatry, Imperial College School of Medicine, London, UK. Professor Charles Bowden MD: Chairman, Department of Psychiatry, The University of Texas Health Science Center at San Antonio Dr Robert W. Buchanan MD: Professor of Psychiatry, Maryland Psychiatric Research Center, Baltimore, USA. Dr Peter F. Buckley MD: Professor and Vicechair, Department of Psychiatry, Case Western Reserve University; Medical Director, Northcoast Behavioral Healthcare System, Cleveland, Ohio, USA. Professor Joseph Calabrese MD: Professor of Psychiatry, Director, Mood Disorders Program, University Hospitals, Department of Psychiatry, Case Western Reserve University, Ohio, USA. Professor Daniel Casey MD: Psychiatry Service, Veterans Affairs Medical Center, Oregon, USA. Dr Robert Conley MD: Associate Professor of Psychiatry, Maryland Psychiatric Research Center, Baltimore, USA. Dr John Cookson MD PhD: Consultant Psychiatrist, Psychiatric Department, The Royal London Hospital, St Clements, London, UK. Dr Stephen Cooper MD FRCPsych: Senior Lecturer, Department of Mental Health, The Queen's University of Belfast, N. Ireland. Dr Ruth Dickson MD FRCP(C): Associate Professor, Department of Psychiatry, University of Calgary, Canada. Professor Ted Dinan MD PhD: Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin. Professor Nicol Ferrier MD: Professor of Psychiatry, School of Neuroscience and Psychiatry, University of Newcastle, Newcastle-upon-Tyne, UK. Professor W. Wolfgang Fleischhacker MD: Professor and Head of the Department of Biological Psychiatry, Department of Psychiatry, Innsbruck University Clinics, Austria. Dr Sophia Frangou MD MSc MRCPsych: Senior Lecturer in Psychiatry, Institute of Psychiatry, London, UK. Dr William Glazer MD: Associate Clinical Professor of Psychiatry, Harvard Medical School, Boston, MA, USA. Professor Siegfried Kasper MD: Professor and Chairman, Department of General Psychiatry, University of Vienna, Austria. Professor Cornelius Katona MD FRCPsych: Department of Psychiatry and Behavioural Sciences, Royal Free and UCL Medical School and Essex and Herts Community NHS Trust, London, UK. Professor Paul Keck MD: Professor and Vice Chairman for Research, University of Cincinnati College of Medicine Dr Jeffrey Kelsey MD PhD: Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA. Professor David King MD FRCPsych FRCP(I) DPM: Professor of Clinical Psychopharmacology, Department of Therapeutics and Pharmacology, Belfast, N. Ireland. Dr Sanjiv Kumra MD, FRCP(C): Center for Addictions and Mental Health and the Hospital for Sick Children, University of Toronto, Canada. Professor Brian Leonard PhD DSc: Pharmacology Department, National University of Ireland, Galway. Professor Shon Lewis MD: Professor of Adult Psychiatry, The University of Manchester, UK. Professor Rasmus W. Licht MD: Chief Psychiatrist and Director of the Mood Disorders Research Unit at the Psychiatric Hospital in Aarhus, Risskov, Denmark; Associate Professor in Clinical Pharmacology at The University of Aarhus, Denmark. Dr Sheila Marcus MD: Director, Adult Ambulatory Division, University of Michigan Health Systems. Professor Stephen R. Marder MD: Professor and Vice Chair, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA. Professor Patrick McGorry MB BS MRCP(UK) FRANZCP PhD: Professor of Psychiatry, University of Melbourne, Victoria, Australia. Dr Peter McKenna MD: Consultant Psychiatrist, Fulbourn Hospital, Cambridge, UK. Professor Kim Mueser PhD: Professor of Psychiatry, Dartmouth Medical School, New Hampshire-Dartmouth Psychiatric Research Center, New Hampshire, USA. Professor Bruno Muller-Oerlinghausen MD: Forschergruppe Klinische Psychopharmakologie, Psychiatrische Klinik und Poliklinik der Freien Universitat Berlin, Germany. Professor Dieter Naber MD: Professor of Psychiatry and Head of Department, Psychiatrische Klinik, Hamburg, Germany. Professor Charles Nemeroff MD PhD: Professor and Chairman, Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA. Professor Willem A. Nolen MD: Professor of Psychiatry, University Medical Centre Utrecht and H.C. Rumke Groep, Willem Arntsz Huis, Utrecht, The Netherlands. Dr Robert Post MD: Chief, NIMH Biological Pyschiatry Branch Bethesda, Maryland, USA. Professor Steven Potkin MD: Professor, Department of Psychiatry; Director, Clinical Psychiatric Research and Robert R. Sprague Director, Brain Imaging Center, University of California, Irvine Dr Barbora Richardson MBBChir MRCGP MRCPsych: Department of Psychiatry and Behavioural Sciences, Royal Free and UCL Medical School, London, UK. Professor Elliott Richelson MD: Professor of Psychiatry and Pharmacology, Mayo Medical School, Rochester, MN Consultant in Psychiatry and Pharmacology, Mayo Clinic Jacksonville, Florida, USA. Dr Gary Sachs MD: Department of Psychiatry, Massachusetts General Hospital, Boston, USA. Professor Alan Schatzberg MD: Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, California, USA. Professor S. Charles Schulz MD: Chair, Department of Psychiatry, University of Minnesota, Minneapolis, USA. Dr Tim Stevens MBBCh MRCPsych: Department of Psychiatry and Behavioural Sciences, Royal Free and UCL Medical School and Essex and Herts Community NHS Trust, London, UK. Dr Trisha Suppes MD PhD: University of Texas Southwestern Medical Center, Associate Professor, Department of Psychiatry; Director, Bipolar Disorder Clinic and Research Program; Bipolar Module Director, Texas Medication Algorithm Project (TMAP) Dr Rajiv Tandon MD: Professor of Psychiatry, Department of Psychiatry, University of Michigan Professor Pamela J. Taylor MB BS MRCP FRCPsych: Professor of Special Hospital Psychiatry, Institute of Psychiatry, London, and Broadmoor Hospital, UK. Professor Michael E. Thase MD: Professor of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA. Dr Madhukar Trivedi MD: Associate Professor of Psychiatry, University of Texas Southwestern Medical Center; Director, Depression and Anxiety Disorders Program, and Director, Depression Module Texas Medication Algorithm Project, Southwest Medical Center, Dallas. Professor John Waddington PhD DSc: Professor of Neuroscience, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin.
Table of Contents
Foreword |
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vii | |
Preface |
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ix | |
Contributors |
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x | |
Section I: Schizophrenia |
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1 | (64) |
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Comparative pharmacology of classical and novel (second-generation) antipsychotics |
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3 | (11) |
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Traditional antipsychotic medications: contemporary clinical use |
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14 | (7) |
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Clozapine: clinical use and experience |
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21 | (11) |
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Risperidone and olanzapine: clinical use and experience |
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32 | (10) |
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Quetiapine and sertindole: clinical use and experience |
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42 | (7) |
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Ziprasidone and zotepine: clinical use and experience |
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49 | (10) |
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Future directions in novel antipsychotics |
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59 | (6) |
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Section II: Depression and Mania |
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65 | (156) |
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Synaptic effects of antidepressants: relationships to their therapeutic and adverse effects |
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67 | (18) |
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Tricyclic antidepressants and classical monoamine oxidase inhibitors: contemporary clinical use |
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85 | (15) |
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Selective serotonin reuptake inhibitors: clinical use and experience |
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100 | (9) |
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Nefazodone, mirtazapine and venlafaxine: clinical use and experience |
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109 | (18) |
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Psychopharmacology of mood stabilizers |
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127 | (28) |
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Lithium: clinical use in mania and prophylaxis of affective disorders |
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155 | (24) |
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Carbamazepine and valproate: use in mood disorders |
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179 | (11) |
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Bruno Muller-Oerlinghausen |
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Lamotrigine, gabapentin and the new anticonvulsants: efficacy in mood disorders |
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190 | (9) |
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Antipsychotic medications in the treatment of mood disorders |
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199 | (13) |
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Future directions in novel antidepressants and mood stabilizing agents |
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212 | (9) |
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Section III: Key Issues in Clinical Psychopharmacology |
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221 | (124) |
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223 | (11) |
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Psychotropic drugs during pregnancy |
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234 | (19) |
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Psychopharmacology in the young |
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253 | (20) |
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Drug treatment of schizophrenia and mood disorders in older people |
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273 | (13) |
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Treatment of substance misuse in schizophrenia |
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286 | (11) |
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Treating violence in the context of psychosis |
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297 | (20) |
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Poor compliance with treatment in people with schizophrenia: causes and management |
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317 | (13) |
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Pharmacoeconomics and resource allocation: lessons from North America |
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330 | (15) |
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Index |
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345 | |