Practical Methods for Biocatalysis and Biotransformations
by Whittall, John; Sutton, Peter W.Edition: 1st
Format: Hardcover
Pub. Date: 2009-12-30
Publisher(s): Wiley
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Summary
Practical Methods for Biocatalysis and Biotransformations is a "how-to" guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips, and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given, and relevant references to the primary literature are cited. Practical Methods for Biocatalysis and Biotransformations is an essential text offering validated biocatalyst methods for researchers and postgraduate students in industry and academia.
Author Biography
John Whittall
CoEBio3, Manchester Interdisciplinary Biocentre, Manchester University, UK
Peter W Sutton
GlaxoSmithKline Research and Development Limited, UK
Table of Contents
| Preface | |
| Abbreviations | |
| Perspectives of Biotransformations in Small Molecule Pharmaceutical Development | |
| Biocatalyst Identification and Scale-Up: Molecular Biology For Chemists | |
| Kinetic Resolutions Using Biotransformations | |
| Stereo- and enantioselective hydrolysis of rac-2-octylsulfate using whole resting cells of Pseudomonas spp | |
| Protease-catalyzed resolutions using the 3-(3-pyridine)propionyl anchor group: p-toluenesulfonamide | |
| Desymmetrisation of prochiral ketones using enzymes | |
| Enzymatic Resolution of 1-Methyl-tetrahydroisoquinoline (1-MTQ) using Candida Rugosa Lipase | |
| Dynamic Kinetic Resolution For the Synthesis of Esters, Amides and Acids Using Lipases | |
| Dynamic Kinetic Resolution of 1-Phenylethanol by Immobilized Lipase Coupled with in-situ Racemization over Zeolite Beta | |
| Synthesis of the (R)-butyrate esters of secondary alcohols by dynamic kinetic resolution employing a bis(Tetrafluorosuccinato)-Bridged Ru(II) Complex | |
| Dynamic Kinetic Resolution of 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline | |
| Dynamic Kinetic Resolution of Primary Amines with a Recyclable Palladium Nanocatalyst (Pd /AlO(OH)) for Racemization | |
| Dynamic Kinetic Resolution of Amines Involving Biocatalysis and in situ Free-Radical-Mediated Racemization | |
| Chemoenzymatic Dynamic Kinetic Resolution of (S)-Ibuprofen | |
| Dynamic kinetic resolution synthesis of a fluorinated amino acid ester amide by a continuous process lipase-mediated ethanolysis of an azalactone | |
| Enzymatic Selectivity in Synthetic Methods | |
| Alcalase Catalyzed Syntheses of Hydrophilic Di- and Tri-peptides in Organic Solvents | |
| Selective alkoxycarbonylation of 1a,25-dihydroxyvitamin D3 diol precursor with Candida antarctica lipase B | |
| The use of lipase enzymes for the synthesis of polymers and polymer intermediates | |
| Bioconversion of t3-cyanopyridine to nicotinic acid with Gordona terrae NDB1165 | |
| Enzyme-promoted desymmetrization of prochiral dinitriles | |
| Epoxide Hydrolase Catalyzed Synthesis of (R)-3-benzyloxy-2-methylpropane-1,2-diol | |
| One-pot biocatalytic synthesis of methyl (S)-4-chloro-3-hydroxybutanoate and methyl (S)-4-cyano-3-hydroxybutanoate Maja Majeric | |
| Aldolase Enzymes For Complex Synthesis | |
| One step synthesis of L-fructose using rhamnulose-1-phosphate aldolase in borate buffer | |
| Straightforward Fructose-1,6-Diphosphate Aldolase mediated synthesis of aminocyclitols | |
| Synthesis of D-fagomine by aldol addition of dihydroxyacetone to N-Cbz-3-aminopropanal catalyzed byD-fructose-6-phosphate aldolase José | |
| Chemoenzymatic Synthesis of 5-Thio-D-Xylopyranose | |
| Enzymatic Synthesis of Glycosides and Glucuronides | |
| Glycosynthase-assisted Oligosaccharide Synthesis | |
| Glycosyl Azides - Novel Substrates for Enzymatic Transglycosylations | |
| Facile synthesis of alkyl ß-D-glucopyranosides from D-glucose and the corresponding alcohols using fruit seed meals | |
| Laccase-Mediated Oxidation of Natural Glycosides | |
| Biocatalyzed synthesis of monoglucuronides of Hydroxytyrosol, Tyrosol, Homovanillic Alcohol, and 3-(4'-Hydroxyphenyl)propanol using liver cells microsomal fractions | |
| Synthesis of the acyl glucuronide of mycophenolic acid | |
| Synthesis of Cyanohydrins Using Hydroxynitrile Lyases | |
| Synthesis of (S)-2-Hydroxy-2-methylbutyric Acid by a Chemoenzymatic Methodology | |
| (S)-Selective cyanohydrin synthesis from aromatic ketones using hydroxynitrile lyases | |
| Hydroxynitrile lyase catalysed synthesis of enantiopure (S)-acetophenone cyanohydrins | |
| (R)- and (S)-Cyanohydrin synthesis from pyridine-3-carboxaldehyde using CLEA-immobilized hydroxynitrile lyases | |
| A new (R)-Hydroxynitrile lyase from Prunus mume for Asymmetric Synthesis of Cyanohydrins | |
| Synthesis of Chiral Sec-Alcohols by Ketone Reduction | |
| Asymmetric synthesis (S)-bis-(trifluoromethyl)phenyl ethanol by biocatalytic reduction of bis-(trifluoromethyl)acetophenone | |
| Enantioselective and diastereoselective enzyme-catalyzed dynamic kinetic resolution of an unsaturated ketone | |
| Enzyme-catalyzed synthesis of a-alkyl-b-hydroxy ketones and esters by isolated ketoreductases | |
| Asymmetric reduction of phenyl ring-containing ketones using xerogel-encapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus | |
| (R)- and (S)- Enantioselective diaryl methanol synthesis using enzymatic reduction of diaryl ketones | |
| Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate, key intermediate for clopidogrel, with recombinant E. coli | |
| Reduction of Functional Groups | |
| Reduction of Carboxylic Acids by Carboxylic Acid Reductase (Car) heterologously expressed in E. coli | |
| Light-driven Stereoselective Biocatalytic Oxidations and Reductions | |
| Unnatural amino acids by enzymatic transamination: synthesis of glutamic acid analogues with aspartate aminotransferase | |
| Synthesis of L-Pipecolic Acid with D1-Piperidine-2-carboxylate Reductase from Pseudomonas putida Hisaaki Mihara and Nobuyoshi Esaki | |
| Synthesis of substituted derivatives of L-phenylalanine and of other non-natural L-amino acids using engineered mutants of phenylalanine dehydrogenase | |
| Enzymatic Oxidation Chemistry | |
| Monoamine Oxidase (MAO-N) Catalysed Reactions: Application Towards the Chemo-Enzymatic Deracemisation of the Alkaloid (±)-Crispine A | |
| Glucose oxidase catalysed synthesis of aldonic acids | |
| Oxidation and halo-hydroxylation of monoterpenes with chloroperoxidase from Caldariomyces fumago | |
| Chloroperoxidase (CPO) Catalyzed Oxidation of Phenyl Methylsulfide in Ionic Liquids | |
| Stereoselective synthesis of b-hydroxy sulfoxides catalyzed by cyclohexanone monooxygenase | |
| Enantioselective kinetic resolution of racemic 3-phenylbutan-2-one using a Baeyer-Villiger monooxygenase | |
| Desymmetrisation of 1-methylbicyclo[3.3.0]octane-2,8-dione by the retro-Claisenase 6-oxo camphor hydrolase | |
| Synthesis of optically pure chiral lactones by cyclopentadecanone monooxygenase (CPDMO)-catalyzed Baeyer-Villiger oxidations | |
| Whole Cell Oxidations and Dehalogenations | |
| Biotransformations of naphthalene to 4-hydroxy-1-tetralone by Streptomyces griseus NRRL 8090 | |
| Hydroxylation of imidacloprid for the synthesis of olefin imidacloprid by Stenotrophomonas maltophilia CGMCC 1.1788 | |
| Biocatalytic synthesis of 6-hydroxy fluvastatin using Motierella rammaniana DSM 62752 in shake flask culture and on multi-gram scale using a Wave bioreactor | |
| Synthesis of 1-adamantanol from adamantane through regioselective hydroxylation by Streptomyces griseoplanus cells | |
| Enantioselective benzylic microbial hydroxylation of indan and tetralin | |
| Stereospecific biotransformation of (R/S)-linalool by Corynespora cassiicola DSM 62475 into linalool oxides | |
| The biocatalytic synthesis of 4-fluorocatechol from fluorobenzene | |
| Synthesis of enantiopure (S)-styrene oxide by selective oxidation of styrene by recombinant E.coli JM101 (pSPZ10) | |
| Biotransformation of a-bromo- and a,a'-dibromo alkanone into a-hydroxyketone and a-diketone by Spirulina platensis | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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