Discover thorough insights into the toxicology of nanomaterials used in medicine 

In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. 

The book is a one-stop resource for recent and comprehensive information on the toxicological and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment.  

Nanotechnology in Medicine: Toxicity and Safety also provides readers with: 

• A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization 
• Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles 
• Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications 
• In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine 

Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists. 

Mahendra Rai, PhD, is Professor in the Department of Biotechnology at Sant Gadge Baba Amravati University, India. Professor Rai has edited more than 60 books and published over 400 research papers and reviews in international peer-reviewed journals.

Mrunali Patel, PhD, is Professor at Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, Gujarat, India. She has written several book chapters and over 100 research papers, reviews, and technical articles. Her research focuses on nanodrug delivery.

Rashmin Patel, PhD, is Professor at Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa,Gujarat, India. He has written several book chapters and over 100 research papers, reviews, and technical articles. His research is focused on nanoassessment.

Preface

List of contributors

Section I: Nanomedicine: Nanotoxicological insights

1 Nanomedicines: Applications and Toxicological Concerns      
Rashmin Patel*
Mrunali Patel
Mahendra Rai

2 Microbial Biopolymers and their Derivatives as Nanotechnological Tools for Medicine: Applications, Advantages, Toxicity and Safety
Paulo Ricardo Franco Marcelino*
Fernanda Gonçalves
Nayelen Sayuri Aizawa
Henrique Paiva Pereira    
Talita Martins Lacerda      
Silvio Silvério da Silva

Section II: Nanoparticles: Toxicity and Safety

3 Selenium Nanoparticles: Toxicity and Safety
Irina A. Shurygina*
Irina S. Trukhan
Nataliya N. Dremina
Michael G. Shurygin

4 Impact of Nanoparticles on Protozoa
Daniel Placha        
Joseph Jampilek*

5 Toxicity of Metallic Nanoparticles: A Pressing Issue
Tejal Mehta* 
Dhaivat Parikh         
Kartik Hariharan  
Namdev Dhas    
Viral Patel

6 Toxicity, Safety and Biodistribution of Multifunctional Mesoporous Silica Nanoparticles
Mansi Paradkar       
Rashmin Patel      
Mrunali Patel*

7 Safety and Toxicity Issues of Polymeric Nanoparticles: A Serious Concern
Priya Patel*
Naimish Vyas
Mihir Raval

8 Green Synthesis of Copper and Copper-based Nanoparticles for their Use in Medicine: Toxicity and Safety
Sadhucharan Mallick*
Piyali Sabui

Section III: Nanotoxicology and Drug delivery

9 Gene Delivery using Nanocarriers: Toxicity and Safety Aspects
Imran Vhora
Nirav Khatri*

10 Toxicity and Safety Evaluation of Lipid-Based Nanoparticles for Brain Delivery
Mitali H. Patel *        
Priyanshi Patel

11 Risk Assessment of Injectable Nanoparticles used as Nanomedicine
Marco Vinícius Chaud*
Fernando Batain
Eliana Barbosa Souto
Patrícia Severino
Thais Francine Ribeiro. Alves

12 Dermatological Delivery of Nanodrugs: Applications, Toxicity and Safety
Saurabh Shivalkar  
Arushi Verma         
Vishal Singh        
Amaresh Kumar Sahoo*

13 Nanonutraceuticals-Considerations for Toxicity and Safety Assessment
Shah Esha Bhavin*
Anuradha Ketan Gajjar

14 Current Challenges and Future Needs for Nanotoxicity and Nanosafety Assessment
Ravish J. Patel* 
Amit Alexander      
Anu Puri          
Bappaditya Chatterjee

Section IV: Nanotechnology, Ethics and Regulatory Framework

15 Safety Regulations for the use of Nanotechnological Products for Biomedical Applications: A Systematic Literature Review          
Raquel Von Hohendorff
Wilson Engelmann*
Daniele Weber S. Leal

16 Nanoethics and Nanotechnology
Iti Chauhan*
Madhu Verma
Dr. Mohd Yasir

17 Current Regulatory Framework in Nanotechnology and Medicine
Nitin Dubey*   
Nidhi Dubey