Immunotherapy of Cancer,9781588295644

Immunotherapy of Cancer

by
ISBN13: 9781588295644
ISBN10: 1588295648
Format: Hardcover
Pub. Date: 2005-12-31
Publisher(s): Humana Pr Inc
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Summary

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Table of Contents

Preface v
Contributors ix
Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches
1(20)
Ozlem Tureci
Thorsten Klamp
Michael Koslowski
Sebastian Kreiter
Ugur Sahin
Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens
21(24)
Ludmila Muller
Stephanie McArdle
Evelyna Derhovanessian
Thomas Flad
Ashley Knights
Robert Rees
Graham Pawelec
Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy
45(14)
Lisa M. Harlan
Julie Y. Djeu
The Role of Immune Monitoring in Evaluating Cancer Immunotherapy
59(14)
Holden T. Maecker
Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials
73(14)
Susan Groshen
DNA Vaccines for Cancer Immunotherapy
87(28)
Heesun Kwak
Howard L. Kaufman
Dendritic Cells
115(12)
Weiping Zou
Tyler J. Curiel
Different Approaches to Dendritic Cell-Based Cancer Immunotherapy
127(12)
Noweeda Mirza
Dmitry Gabrilovich
Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer
139(12)
Malaya Bhattacharya-Chatterjee
Nitin Rohatgi
Sunil K. Chatterjee
Asim Saha
Rakesh Shukla
Kenneth A. Foon
Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics
151(16)
Jie Dai
Zihai Li
Tumor-Reactive T-Cells for Adoptive Immunotherapy
167(14)
Helga Bernhard
Julia Neudorfer
Kerstin Gebhard
Heinke Conrad
Dirk H. Busch
Christian Peschel
T-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical Significance
181(32)
Peter A. Cohen
Mohamed Awad
Suyu Shu
Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells
213(22)
Jeffrey J. Roszkowski
Michael I. Nishimura
Harnessing the Potential of Graft-vs-Tumor
235(28)
Nancy M. Hardy
Michael R. Bishop
Tumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome of Immunotherapy of Malignant Disease
263(22)
Michael Campoli
Soldano Ferrone
The Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for Immunotherapy
285(18)
George Coukos
Jose-Ramon Conejo-Garcia
Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity
303(14)
Eduardo Davila
Esteban Celis
Fast-Lane Evolution in the Tumor Microenvironment
317(14)
Gabriella Marincola
Francesco M. Marincola
Manipulating Immunological Checkpoints to Maximize Antitumor Immunity
331(24)
Leisha A. Emens
R. Todd Reilly
Elizabeth M. Jaffee
Interleukin-2 as Cancer Therapy
355(10)
Joseph I. Clark
Kim A. Margolin
Biological and Clinical Properties of the Type 1 Interferons
365(32)
Douglas W. Leaman
Shaun Rosebeck
Ernest C. Borden
Promising γ-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and Immuno restoratives
397(18)
Terry J. Fry
Crystal L. Mackall
The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies
415(18)
Sherif S. Farag
Michael A. Caligiuri
Antibody Therapy for Solid Tumors
433(12)
Cristina I. Truica
Dorinda Rouch
Carlos L. Arteaga
Antibody Therapy for Non-Hodgkin's Lymphoma
445(12)
Stephen M. Ansell
Thomas E. Witzig
Approaches to In Vivo Imaging of Cancer Immunotherapy
457(22)
George A. Vielhauer
Bond Almand
Mary L. Disis
David A. Mankoff
Keith L. Knutson
Design Issues for Early-Stage Clinical Trials for Cancer Vaccines
479(8)
Gina R. Petroni
Monoclonal Antibody Therapy of Cancer
487(16)
Hossein Borghaei
Matthew K. Robinson
Louis M. Weiner
Index 503

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