Gain a thorough understanding of the principles of biochemistry as they relate to the study of clinical medicine

THE BEST REVIEW FOR THE USMLE!

The Thirtieth Edition of Harper’s Illustrated Biochemistry combines outstanding full-color illustrations with authoritative integrated coverage of biochemical disease and clinical information. Using brevity and numerous medically relevant examples, Harper's presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.

All fifty-eight chapters emphasize the medical relevance of biochemistry

• Full-color presentation includes more than 600 illustrations
• Each chapter includes a section on Biomedical Importance and a summary of the topics covered
• Review questions follow each of the eleven sections
• Case studies in every chapter emphasize the clinical relevance to biochemistry
• NEW coverage of toxic naturally-occurring amino acids; extraterrestrial biomolecules; computer-aided drug design; the role of complement cascade in bacterial and viral infection; secreted mediators of cell-cell signaling between leukocytes; the role of mast cells, basophils, and eosinophils; and the hazard of antioxidants that down-regulate radical signaling for apoptosis and increase risk of cancer

Applauded by medical students for its current and engaging style, Harper's Illustrated Biochemistry is an essential for USMLE review and the single best reference for learning the clinical relevance of any biochemistry topic.

1Biochemistry & Medicine 1

Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD

2 Water & pH 6

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

3 Amino Acids & Peptides 15

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

4 Proteins: determination of Primary Structure 25

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

5 Proteins: Higher Orders of Structure 36

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

6 Proteins: Myoglobin & Hemoglobin 51

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

7 Enzymes: Mechanism of Action 60

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

8 Enzymes: Kinetics 73

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

9 Enzymes: Regulation of Activities 87

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

10 Bioinformatics & Computational

Biology 97

Peter J. Kennelly, PhD & Victor W. Rodwell, PhD

11 Bioenergetics: The Role of ATP 113

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

12 Biologic Oxidation 119

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

13 The Respiratory Chain & Oxidative

Phosphorylation 126

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

14 Overview of Metabolism & the Provision

of Metabolic Fuels 139

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

15 Carbohydrates of Physiological

Significance 152

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

16 The Citric Acid Cycle: The Central Pathway

of Carbohydrate, Lipid & Amino Acid

Metabolism 161

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

17 Glycolysis & the Oxidation of Pyruvate 168

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

18 Metabolism of Glycogen 176

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

19 Gluconeogenesis & the Control of Blood

Glucose 185

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

20 The Pentose Phosphate Pathway & Other

Pathways of Hexose Metabolism 196

David A. Bender, PhD & Peter A. Mayes, PhD, DSc

21 Lipids of Physiologic Significance 211

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

22 Oxidation of Fatty Acids: Ketogenesis 223

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

23 Biosynthesis of Fatty

Acids & Eicosanoids 232

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

24 Metabolism of Acylglycerols

& Sphingolipids 245

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

25 Lipid Transport & Storage 253

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

26 Cholesterol Synthesis, Transport,

& Excretion 266

Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc

27 Biosynthesis of the Nutritionally

Nonessential Amino Acids 281

Victor W. Rodwell, PhD

28 Catabolism of Proteins & of Amino Acid

Nitrogen 287

Victor W. Rodwell, PhD

29 Catabolism of the Carbon Skeletons of

Amino Acids 297

Victor W. Rodwell, PhD

30 Conversion of Amino Acids to Specialized

Products 313

Victor W. Rodwell, PhD

31 Porphyrins & Bile Pigments 323

Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD

32 Nucleotides 339

Victor W. Rodwell, PhD

33 Metabolism of Purine & Pyrimidine

Nucleotides 347

Victor W. Rodwell, PhD

34 Nucleic Acid Structure & Function 359

P. Anthony Weil, PhD

35 DNA Organization, Replication,

& Repair 370

P. Anthony Weil, PhD

36 RNA Synthesis, Processing,

& Modification 394

P. Anthony Weil, PhD

37 Protein Synthesis & the Genetic Code 413

P. Anthony Weil, PhD

38 Regulation of Gene Expression 428

P. Anthony Weil, PhD

39 Molecular Genetics, Recombinant DNA,

& Genomic Technology 451

P. Anthony Weil, PhD

40 Membranes: Structure

& Function 477

Robert K. Murray, MD, PhD & P. Anthony Weil, PhD

41 The Diversity of the Endocrine

System 498

P. Anthony Weil, PhD

42 Hormone Action & Signal

Transduction 518

P. Anthony Weil, PhD

43 Nutrition, Digestion,

& Absorption 537

David A. Bender, PhD & Peter A. Mayes , PhD, DSc

44 Micronutrients: Vitamins

& Minerals 546

David A. Bender, PhD

45 Free Radicals & Antioxidant

Nutrients 564

David A. Bender, PhD

46 Glycoproteins 569

David A. Bender, PhD & Robert K. Murray, MD, PhD

47 Metabolism of Xenobiotics 583

David A. Bender, PhD & Robert K. Murray, MD, PhD

48 Clinical Biochemistry 589

David A. Bender, PhD, Joe Varghese, MBBS, MD,

Molly Jacob, MBBS, MD, PhD, & Robert K.

Murray, MD, PhD

49 Intracellular Traffic & Sorting of Proteins 607

Kathleen M. Botham , PhD, DSc & Robert K. Murray, MD, PhD

50 The Extracellular Matrix 627

Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD

51 Muscle & the Cytoskeleton 647

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD

52 Plasma Proteins & Immunoglobulins 668

Peter J. Kennelly, PhD, Robert K. Murray, MD, PhD, Molly

Jacob, MBBS, MD, PhD & Joe Varghese, MBBS, MD

53 Red Blood Cells 689

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD

54 White Blood Cells 700

Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD

55 Hemostasis & Thrombosis 711

Peter L. Gross, MD, MSc, FRCP(C), Robert K. Murray, MD, PhD,

P. Anthony Weil, PhD, & Margaret L. Rand, PhD

56 Cancer: An Overview 722

Molly Jacob, MBBS, MD, PhD, Joe Varghese, MBBS, MD,

Robert K. Murray, MD, PhD & P. Anthony Weil, PhD

57 Biochemical Case Histories 746

David A. Bender, PhD

58 The Biochemistry of Aging 755

Peter J. Kennelly, PhD