From Melanocytes To Melanoma,9781588294593

From Melanocytes To Melanoma

by ;
ISBN13: 9781588294593
ISBN10: 1588294595
Format: Hardcover
Pub. Date: 2006-02-01
Publisher(s): Humana Pr Inc
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Summary

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

Table of Contents

Preface v
Acknowledgment vii
Contributors xiii
List of Color Plates
xvii
Part I. Melanocyte Development and Function
The Origin and Development of Neural Crest-Derived Melanocytes
3(24)
Debra L. Silver
William J. Pavan
MITF: A Matter of Life and Death for Developing Melanocytes
27(24)
Heinz Arnheiter
Ling Hou
Minh-Thanh T. Nguyen
Keren Bismuth
Tamas Csermely
Hideki Murakami
Susan Skuntz
Wen Fang Liu
Kapil Bharti
MITF: Critical Regulator of the Melanocyte Lineage
51(20)
Erez Feige
Laura L. Poling
David E. Fisher
Melanocytes and the Transcription Factor Sox 10
71(10)
Michael Wegner
Human Cutaneous Pigmentation: A Collaborative Act in the Skin, Directed by Paracrine, Autocrine, and Endocrine Factors and the Environment
81(20)
Zalfa A. Abdel-Malek
Ana Luisa Kadekaro
Melanocyte Distribution and Function in Human Skin: Effects of Ultraviolet Radiation
101(18)
Yuji Yamaguchi
Vincent J. Hearing
Part II. Melanocyte Transformation and Progression to Melanoma
Altered Signal Transduction in Melanoma
119(30)
Pablo Lopez Bergami
Anindita Bhoumik
Ze'ev Ronai
BRN2 in Melanocytic Cell Development, Differentiation, and Transformation
149(20)
Anthony L. Cook
Glen M. Boyle
J. Helen Leonard
Peter G. Parsons
Richard A. Sturm
The Dynamic Roles of Cell-Surface Receptors in Melanoma Development
169(14)
Dong Fang
Meenhard Herlyn
Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation
183(14)
Dorothy C. Bennett
Genetic Progression From Melanocyte to Malignant Melanoma
197(14)
Boris C. Bastian
The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma
211(12)
Dahu Chen
Qiushi Lin
I. Saira Mian
Jon Reed
Estela E. Medrano
RB/E2F Regulation and Dual Activity in the Melanocytic System
223(24)
Ruth Halaban
Melanoma Development and Pigment Cell Transformation
247(18)
Claudia Wellbrock
The Biology and Genetics of Melanoma
265(26)
Norman E. Sharpless
Lynda Chin
The Biology of Xeroderma Pigmentosum: Insights Into the Role of Ultraviolet Light in the Development of Melanoma
291(20)
James E. Cleaver
Divergent Pathways to Cutaneous Melanoma
311(18)
David C. Whiteman
Adele C. Green
Pigmentation, DNA Repair, and Candidate Genes: The Risk of Cutaneous Malignant Melanoma in a Mediterranean Population
329(18)
Maria Teresa Landi
Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology
347(18)
Peter A. Kanetsky
Timothy R. Rebbeck
The Biology of Melanoma Progression: From Melanocyte to Metastatic Seed
365(34)
A. Neil Crowson
Cynthia Magro
Martin C. Mihm, Jr.
Optical Imaging Analysis of Atypical Nevi and Melanoma
399(10)
Amanda Pfaff Smith
Dorothea Becker
Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes
409(20)
Katheryn A. Resing
Natalie G. Ahn
Part III. Primary Invasive Melanoma to Metastatic Melanoma
Paradigm of Metastasis for Malignant Melanoma
429(12)
Stanley P. L. Leong
Repair of UV-Induced DNA Damage and Melanoma Risk
441(14)
Qingyi Wei
High-Risk Factors for Melanoma Metastasis
455(20)
Neil A. Accortt
Seng-jaw Soong
Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma
475(14)
Anja-Katrin Bosserhoff
Role and Regulation of PAR-1 in Melanoma Progression
489(14)
Carmen Tellez
Menashe Bar-Eli
Molecular Mechanisms of Melanoma Metastasis
503(10)
Mohammed Kashani-Sabet
Overview of Tumor Progression in Melanoma
513(20)
David E. Elder
The Plasticity of Melanoma Cells and Associated Clinical Implications
533(18)
Mary J. C. Hendrix
Elisabeth A. Seftor
Angela R. Hess
Richard E. B. Seftor
The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma
551(26)
Steve R. Martinez
Hiroya Takeuchi
Dave S. B. Hoon
The Role of DCT/TYRP2 in Resistance of Melanoma Cells to Drugs and Radiation
577(14)
Brian J. Pak
Yaacov Ben-David
How Melanoma Cells Evade Chemotherapy: Role of Transporter-Dependent and -Independent Resistance Mechanisms
591(14)
Kevin G. Chen
Michael M. Gottesman
Apoptosis in Melanoma: Approaches to Therapy
605(14)
Heike Rockmann
Dirk Schadendorf
Role of Melanoma-Associated Antigens
619(14)
Rishab K. Gupta
Ana M. McElrath-Garza
Donald L. Morton
Host Responses to Melanoma: Implications for Immunotherapy
633(18)
Julian A. Kim
Ernest Borden
Future Perspectives
651(2)
Vincent J. Hearing
Stanley P. L. Leong
Index 653

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