| SECTION I Introduction to Molecular Medicine |
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1 | (12) |
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The Molecular Basis of Human Disease |
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3 | (10) |
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Deoxyribonucleic Acid and the Genetic Code |
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3 | (2) |
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Regulation of Gene Expression |
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5 | (2) |
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Genetic Variation, Population Diversity, and Genetic Polymorphisms |
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7 | (1) |
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8 | (1) |
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9 | (1) |
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10 | (1) |
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11 | (1) |
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12 | (1) |
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12 | (1) |
| SECTION II Decision-Making in Medical Practice |
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13 | (6) |
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15 | (4) |
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Searching for Relevant Information |
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15 | (1) |
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Critical Appraisal of the Literature |
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16 | (1) |
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Evaluating Evidence About Diagnostic Tests |
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16 | (1) |
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Evaluating Evidence About Outcome |
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17 | (1) |
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Evaluating Evidence About Treatment |
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17 | (1) |
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Including the Patient in the Decision Process |
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18 | (1) |
| SECTION III Cardiovascular Disease |
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19 | (146) |
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Structure and Function of the Normal Heart and Blood Vessels |
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21 | (9) |
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21 | (1) |
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21 | (1) |
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22 | (1) |
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23 | (1) |
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24 | (1) |
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Physiology of Contraction |
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24 | (1) |
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Circulatory Physiology and the Cardiac Cycle |
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24 | (1) |
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25 | (2) |
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Physiology of the Coronary Circulation |
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27 | (1) |
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Physiology of the Systemic Circulation |
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28 | (1) |
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Physiology of the Pulmonary Circulation |
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28 | (1) |
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Cardiovascular Response to Exercise |
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29 | (1) |
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Evaluation of the Patient with Cardiovascular Disease |
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30 | (13) |
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30 | (4) |
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34 | (3) |
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37 | (6) |
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Diagnostic Tests and Procedures in the Patient with Cardiovascular Disease |
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43 | (13) |
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43 | (1) |
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43 | (2) |
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45 | (2) |
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Long-Term Ambulatory ECG Recording |
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47 | (1) |
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48 | (2) |
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50 | (2) |
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52 | (1) |
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52 | (1) |
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Right-Sided Heart Catheterization |
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53 | (1) |
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53 | (2) |
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Noninvasive Vascular Testing |
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55 | (1) |
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Heart Failure and Cardiomyopathy |
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56 | (7) |
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56 | (1) |
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Adaptive Mechanisms in Heart Failure |
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56 | (1) |
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Evaluation and Treatment of Patients with Heart Failure |
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57 | (2) |
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59 | (1) |
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60 | (1) |
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Cardiovascular Assist Devices |
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61 | (1) |
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61 | (1) |
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61 | (2) |
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63 | (6) |
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63 | (1) |
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Fetal and Transitional Circulations |
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63 | (1) |
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Congenital Aortic Stenosis |
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63 | (1) |
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64 | (1) |
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65 | (1) |
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65 | (1) |
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66 | (1) |
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Ventricular Septal Defect |
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67 | (1) |
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68 | (1) |
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Other Congenital Abnormalities |
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68 | (1) |
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Acquired Valvular Heart Disease |
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69 | (10) |
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69 | (1) |
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70 | (2) |
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72 | (2) |
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74 | (1) |
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74 | (1) |
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75 | (1) |
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75 | (1) |
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Pulmonic Stenosis and Regurgitation |
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76 | (1) |
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76 | (1) |
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76 | (1) |
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77 | (1) |
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77 | (2) |
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79 | (21) |
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79 | (1) |
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Pathophysiology of Atherosclerosis |
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79 | (1) |
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80 | (1) |
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Nonatherosclerotic Causes of Cardiac Ischemia |
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81 | (1) |
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Pathophysiology and Consequences of Myocardial Ischemia |
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82 | (1) |
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82 | (8) |
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Acute Myocardial Infarction |
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90 | (10) |
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100 | (27) |
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Mechanisms of Arrhythmogenesis |
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100 | (3) |
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Approach to the Patient with Suspected Arrhythmias |
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103 | (1) |
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Management of Cardiac Arrhythmias |
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104 | (7) |
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111 | (9) |
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120 | (2) |
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122 | (3) |
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Principles of Cardiopulmonary Resuscitation |
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125 | (2) |
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Myocardial and Pericardial Disease |
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127 | (10) |
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127 | (1) |
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128 | (3) |
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131 | (1) |
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132 | (5) |
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137 | (8) |
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137 | (1) |
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138 | (1) |
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139 | (1) |
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Noncardiac Surgery in the Cardiac Patient |
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140 | (2) |
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Cardiac Disease in Pregnancy |
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142 | (1) |
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Specific Cardiac Conditions |
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142 | (3) |
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Vascular Diseases and Hypertension |
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145 | (20) |
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Systemic Vascular Disease |
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145 | (7) |
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Venous Thromboembolic Disease |
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152 | (3) |
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Pulmonary Vascular Disease |
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155 | (2) |
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157 | (8) |
| SECTION IV Pulmonary and Critical Care Medicine |
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165 | (56) |
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Approach to the Patient with Respiratory Disease |
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167 | (5) |
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Common Presenting Complaints |
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167 | (2) |
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169 | (3) |
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Anatomic and Physiologic Consideration |
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172 | (9) |
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172 | (1) |
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173 | (4) |
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Abnormalities of Pulmonary Gas Exchange |
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177 | (4) |
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Diagnostic Techniques and Their Indications |
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181 | (4) |
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181 | (1) |
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Evaluation of Lung Function |
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181 | (4) |
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185 | (9) |
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Pathophysiology of Air Flow Obstruction |
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185 | (1) |
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186 | (1) |
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Chronic Obstructive Pulmonary Disease |
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187 | (2) |
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189 | (1) |
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189 | (1) |
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190 | (4) |
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Interstitial and Infiltrative Lung Disease |
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194 | (7) |
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Pathophysiology and Clinical Manifestations |
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194 | (7) |
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Disorders of the Pleural Space, Mediastinum, and Chest Wall |
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201 | (5) |
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201 | (2) |
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203 | (1) |
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203 | (3) |
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Neoplastic Diseases of the Lung |
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206 | (4) |
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206 | (1) |
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206 | (1) |
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206 | (1) |
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207 | (1) |
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Solitary Pulmonary Nodule |
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208 | (1) |
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209 | (1) |
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210 | (3) |
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210 | (1) |
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Other Breathing Disorders |
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211 | (2) |
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Environmental and Occupational Injury |
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213 | (3) |
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213 | (1) |
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213 | (1) |
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214 | (1) |
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214 | (1) |
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215 | (1) |
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Drowning and Near-Drowning |
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215 | (1) |
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Essentials of Pulmonary Critical Care Medicine |
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216 | (5) |
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216 | (1) |
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Acute Respiratory Failure |
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217 | (1) |
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217 | (1) |
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218 | (1) |
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Complications of Endotracheal Intubation and Mechanical Ventilation |
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219 | (1) |
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Systemic Inflammatory Response Syndrome, Sepsis, Multiple Organ Dysfunction Syndrome, and Adult Respiratory Distress Syndrome |
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219 | (2) |
| SECTION V Renal Disease |
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221 | (80) |
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Elements of Renal Structure and Function |
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223 | (9) |
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Elements of Renal Structure |
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223 | (3) |
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Elements of Renal Physiology |
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226 | (6) |
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Approach to the Patient with Renal Disease |
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232 | (6) |
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Assessment of the Patient with Renal Disease |
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232 | (2) |
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The Major Renal Syndromes |
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234 | (2) |
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Radiologic Imaging of the Urinary Tract |
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236 | (1) |
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237 | (1) |
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Fluid and Electrolyte Disorders |
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238 | (15) |
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238 | (3) |
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241 | (1) |
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242 | (2) |
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244 | (1) |
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Disturbances in Potassium Balance |
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245 | (3) |
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Disturbances in Acid-Base Balance |
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248 | (5) |
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253 | (13) |
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253 | (1) |
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Mechanisms of Glomerular Injury |
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253 | (1) |
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Clinical Manifestations of Glomerular Disease |
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253 | (2) |
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Approach to the Patient with Glomerular Disease |
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255 | (1) |
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255 | (2) |
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Rapidly Progressive Glomerulonephritis |
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257 | (1) |
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258 | (5) |
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Asymptomatic Urinary Abnormalities |
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263 | (3) |
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Major Nonglomerular Disorders |
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266 | (12) |
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Tubulointerstitial Nephropathy |
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266 | (3) |
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Cystic Diseases of the Kidney |
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269 | (2) |
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Urinary Tract Obstruction |
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271 | (1) |
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272 | (3) |
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275 | (3) |
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Vascular Disorders of the Kidney |
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278 | (5) |
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278 | (1) |
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278 | (1) |
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Arterioles and Microvasculature |
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279 | (1) |
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Atheroembolic Diseases of the Kidney |
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279 | (1) |
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Chronic Hypertensive Nephrosclerosis |
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280 | (1) |
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Malignant Nephrosclerosis |
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280 | (1) |
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280 | (1) |
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Hemolytic-Uremic Syndrome and Thrombotic Thrombocytopenic Purpura |
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281 | (1) |
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Antiphospholipid Syndrome and the Kidney |
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281 | (1) |
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282 | (1) |
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283 | (8) |
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283 | (1) |
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Differential Diagnosis and Diagnostic Evaluation of the Patient |
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283 | (4) |
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Clinical Presentation, Complications, and Management of Acute Tubular Necrosis |
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287 | (1) |
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Specific Causes of Acute Renal Failure |
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288 | (3) |
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291 | (10) |
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Adaptation to Nephron Loss |
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291 | (1) |
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292 | (1) |
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293 | (3) |
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Treatment of End-Stage Renal Failure |
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296 | (5) |
| SECTION VI Gastrointestinal Disease |
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301 | (64) |
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Common Clinical Manifestations of Gastrointestinal Disease |
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303 | (18) |
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303 | (3) |
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303 | (1) |
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303 | (1) |
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303 | (2) |
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305 | (1) |
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305 | (1) |
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Gastrointestinal Hemorrhage |
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306 | (4) |
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Acute Gastrointestinal Hemorrhage |
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306 | (3) |
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Chronic Gastrointestinal Hemorrhage |
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309 | (1) |
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310 | (6) |
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Digestion and Absorption of Fat |
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310 | (1) |
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Digestion and Absorption of Carbohydrates |
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310 | (1) |
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Digestion and Absorption of Proteins |
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310 | (1) |
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Mechanisms of Malabsorption |
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310 | (1) |
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311 | (1) |
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Clinical Manifestations of Malabsorption |
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311 | (1) |
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312 | (2) |
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Approach to the Patient with Suspected Malabsorption |
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314 | (1) |
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314 | (2) |
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316 | (5) |
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316 | (1) |
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316 | (1) |
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317 | (1) |
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318 | (3) |
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Endoscopic and Radiographic Procedures in Gastroenterology |
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321 | (5) |
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Gastrointestinal Endoscopy |
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321 | (1) |
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Esophagogastroduodenoscopy and Enteroscopy |
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321 | (1) |
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Endoscopic Retrograde Cholangiopancreatography |
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322 | (1) |
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Endoscopic Ultrasonography |
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323 | (1) |
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Sigmoidoscopy and Colonoscopy |
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323 | (1) |
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323 | (3) |
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Diseases of the Esophagus |
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326 | (6) |
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Normal Esophageal Physiology |
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326 | (1) |
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Clinical Symptoms of Esophageal Disease |
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326 | (1) |
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Gastroesophageal Reflux Disease |
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327 | (2) |
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Motility Disorders of the Oropharynx and Esophagus |
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329 | (1) |
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Other Esophageal Disorders |
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330 | (2) |
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Diseases of the Stomach and Duodenum |
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332 | (13) |
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332 | (1) |
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Gastroduodenal Mucosal Secretion and Protective Factors |
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332 | (1) |
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Gastroduodenal Motor Physiology |
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333 | (1) |
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334 | (1) |
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335 | (6) |
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Zollinger-Ellison Syndrome |
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341 | (1) |
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342 | (1) |
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343 | (2) |
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Inflammatory Bowel Disease |
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345 | (6) |
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345 | (1) |
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Incidence and Epidemiology |
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345 | (1) |
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Ulcerative Colitis: Clinical Features |
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346 | (1) |
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Crohn's Disease: Clinical Features |
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346 | (1) |
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Extraintestinal Manifestations |
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346 | (1) |
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346 | (1) |
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347 | (1) |
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347 | (1) |
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347 | (1) |
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347 | (4) |
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Neoplasms of the Gastrointestinal Tract |
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351 | (5) |
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351 | (1) |
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352 | (1) |
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Colorectal Polyps and Carcinoma |
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353 | (1) |
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354 | (1) |
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355 | (1) |
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356 | (9) |
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356 | (2) |
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358 | (3) |
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361 | (1) |
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Carcinoma of the Pancreas |
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362 | (3) |
| SECTION VII Diseases of the Liver and Biliary System |
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365 | (38) |
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Laboratory Tests in Liver Disease |
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367 | (4) |
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Clinical Approach to Liver Disease |
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367 | (1) |
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Laboratory Tests of Liver Function and Disease |
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367 | (3) |
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370 | (1) |
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371 | (5) |
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371 | (1) |
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Laboratory Tests for Bilirubin |
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371 | (1) |
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372 | (2) |
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374 | (2) |
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Acute and Chronic Hepatitis |
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376 | (9) |
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376 | (7) |
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383 | (2) |
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Fulminant Hepatic Failure |
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385 | (2) |
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385 | (1) |
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385 | (1) |
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386 | (1) |
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386 | (1) |
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Cirrhosis of the Liver and its Complications |
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387 | (7) |
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Clinical and Laboratory Features |
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387 | (1) |
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387 | (1) |
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388 | (4) |
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392 | (2) |
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Neoplastic, Infiltrative, and Vascular Diseases of the Liver |
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394 | (4) |
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|
|
|
|
|
|
|
|
|
394 | (1) |
|
|
|
395 | (1) |
|
Granulomatous Liver Disease |
|
|
395 | (1) |
|
Diagnostic Approach to Hepatic Lesions |
|
|
396 | (1) |
|
Vascular Disease of the Liver |
|
|
396 | (2) |
|
Disorders of the Gallbladder and Biliary Tract |
|
|
398 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Normal Biliary Physiology |
|
|
398 | (1) |
|
Pathophysiology of Gallstone Formation (Cholelithiasis) |
|
|
398 | (1) |
|
Clinical Manifestations of Gallstones |
|
|
399 | (4) |
| SECTION VIII Hematologic Disease |
|
403 | (80) |
|
Hematopoiesis and Hematopoetic Failure |
|
|
405 | (5) |
|
|
|
|
|
|
|
|
|
|
|
|
|
405 | (1) |
|
Stem Cell Theory of Hematopoiesis |
|
|
405 | (1) |
|
Hematopoietic Differentiation Pathway |
|
|
406 | (2) |
|
Disorders of Hematopoiesis |
|
|
408 | (2) |
|
Clonal Disorders of the Hematopoietic Stem Cell |
|
|
410 | (9) |
|
|
|
|
|
|
|
|
|
|
|
Myelodysplastic Disorders |
|
|
410 | (2) |
|
Myeloproliferative Disorders |
|
|
412 | (2) |
|
Chronic Myelogenous Leukemia |
|
|
414 | (1) |
|
|
|
415 | (4) |
|
Disorders of Red Blood Cells |
|
|
419 | (12) |
|
|
|
|
|
|
Normal Red Blood Cell Structure and Function |
|
|
419 | (1) |
|
Clinical Approach to Anemia |
|
|
419 | (1) |
|
Evaluation of Hypoproliferative Anemia |
|
|
420 | (11) |
|
Clinical Disorders of Neutrophils |
|
|
431 | (4) |
|
|
|
|
|
|
Normal Granulocyte Development, Structure, and Function |
|
|
431 | (1) |
|
Determinants of Peripheral Neutrophil Number |
|
|
432 | (1) |
|
Evaluation of Leukocytosis (Neutrophilia) |
|
|
433 | (1) |
|
Evaluation of Leukopenia (Neutropenia) |
|
|
433 | (2) |
|
|
|
435 | (14) |
|
|
|
|
|
|
Cells of the Immune System: Lymphocyte Development, Function, and Localization |
|
|
435 | (2) |
|
Neoplasia of Lymphoid Origin |
|
|
437 | (12) |
|
|
|
449 | (8) |
|
|
|
|
|
|
|
|
449 | (1) |
|
|
|
450 | (3) |
|
|
|
453 | (3) |
|
Endothelial-Associated Fibrinolysis |
|
|
456 | (1) |
|
Disorders of Hemostasis: Bleeding |
|
|
457 | (16) |
|
|
|
|
|
|
Clinical Evaluation of Bleeding |
|
|
457 | (1) |
|
Vascular Causes of Bleeding |
|
|
457 | (2) |
|
Bleeding Caused by Platelet Disorders: Thrombocytopenia |
|
|
459 | (6) |
|
Bleeding Caused by Platelet Disorders: Qualitative Platelet Defects |
|
|
465 | (3) |
|
|
|
468 | (1) |
|
Bleeding Caused by Coagulation Factor Disorders |
|
|
469 | (2) |
|
Bleeding in Patients with a Normal Laboratory Screen |
|
|
471 | (2) |
|
Disorders of Hemostasis: Thrombosis |
|
|
473 | (10) |
|
|
|
|
|
|
Clinical Evaluation of Thrombosis |
|
|
473 | (1) |
|
Vascular Causes of Thrombosis |
|
|
473 | (1) |
|
|
|
473 | (2) |
|
Inherited Risk Factors for Venous Thrombosis |
|
|
475 | (1) |
|
Acquired Risk Factors for Venous Thrombosis |
|
|
476 | (1) |
|
Hypercoagulability and Platelet Disorders |
|
|
477 | (1) |
|
Laboratory Evaluation of Thrombosis |
|
|
477 | (1) |
|
Therapy for Venous Thromboembolism |
|
|
478 | (2) |
|
Venous Thromboembolism During Pregnancy |
|
|
480 | (1) |
|
Perioperative Anticoagulation |
|
|
480 | (1) |
|
Future Anticoagulant Strategies |
|
|
481 | (2) |
| SECTION IX Oncologic Disease |
|
483 | (30) |
|
Cancer Etiology: Oncogenes and Environmental/Toxic Factors |
|
|
485 | (4) |
|
|
|
|
|
|
|
|
485 | (1) |
|
|
|
485 | (1) |
|
|
|
486 | (3) |
|
Cancer Epidemiology and Cancer Prevention |
|
|
489 | (4) |
|
|
|
|
|
|
|
|
489 | (1) |
|
|
|
489 | (4) |
|
|
|
493 | (12) |
|
|
|
|
|
|
|
|
|
|
|
|
|
493 | (2) |
|
|
|
495 | (3) |
|
|
|
498 | (1) |
|
|
|
499 | (4) |
|
|
|
503 | (2) |
|
|
|
505 | (3) |
|
|
|
|
|
|
|
|
505 | (1) |
|
Superior Vena Cava Syndrome |
|
|
506 | (1) |
|
|
|
506 | (1) |
|
|
|
507 | (1) |
|
Principles of Cancer Treatment |
|
|
508 | (5) |
|
|
|
|
|
|
|
|
508 | (1) |
|
|
|
508 | (1) |
|
|
|
508 | (1) |
|
|
|
509 | (1) |
|
|
|
510 | (1) |
|
|
|
511 | (1) |
|
|
|
511 | (1) |
|
Bone Marrow Transplantation |
|
|
511 | (2) |
| SECTION X Metabolic Disease |
|
513 | (30) |
|
|
|
515 | (7) |
|
|
|
|
|
|
|
|
515 | (4) |
|
Anorexia Nervosa and Bulimia Nervosa |
|
|
519 | (3) |
|
Principles of Nutritional Support in Adult Patients |
|
|
522 | (4) |
|
|
|
|
|
|
|
|
522 | (1) |
|
Route of Nutritional Support |
|
|
522 | (1) |
|
|
|
523 | (1) |
|
|
|
523 | (1) |
|
|
|
524 | (1) |
|
|
|
524 | (2) |
|
Disorders of Lipid Metabolism |
|
|
526 | (7) |
|
|
|
|
|
|
Plasma Lipoprotein Physiology |
|
|
526 | (1) |
|
Evaluation of Serum Lipoprotein Concentrations |
|
|
527 | (1) |
|
Elevated Chylomicrons, VLDL, and IDL |
|
|
528 | (1) |
|
Treatment of Hypertriglyceridemia |
|
|
529 | (1) |
|
|
|
530 | (1) |
|
Treatment of Hypercholesterolemia |
|
|
530 | (1) |
|
Lipids and Vascular Disease |
|
|
531 | (2) |
|
Disorders of Metals and Metalloproteins |
|
|
533 | (6) |
|
|
|
|
|
|
|
|
533 | (1) |
|
|
|
534 | (1) |
|
|
|
534 | (2) |
|
|
|
536 | (3) |
|
Inherited Disorders of Connective Tissue |
|
|
539 | (4) |
|
|
|
|
|
|
|
|
539 | (1) |
|
|
|
540 | (1) |
|
|
|
541 | (2) |
| SECTION XI Endocrine Disease |
|
543 | (62) |
|
Hypothalamic-Pituitary Axis |
|
|
545 | (10) |
|
|
|
|
|
|
|
|
545 | (1) |
|
Anterior Pituitary Hormone Physiology and Testing |
|
|
545 | (3) |
|
Neuroradiologic Evaluation of the Pituitary Gland |
|
|
548 | (1) |
|
Pituitary and Hypothalamic Disorders |
|
|
548 | (2) |
|
|
|
550 | (2) |
|
The Posterior Pituitary Gland |
|
|
552 | (3) |
|
|
|
555 | (9) |
|
|
|
|
|
|
|
|
|
|
|
Thyroid Hormone Physiology |
|
|
555 | (1) |
|
|
|
556 | (1) |
|
|
|
557 | (1) |
|
|
|
557 | (2) |
|
|
|
559 | (1) |
|
Toxic Multinodular Goiter |
|
|
559 | (1) |
|
|
|
559 | (1) |
|
|
|
560 | (1) |
|
Rare Causes of Thyrotoxicosis |
|
|
560 | (1) |
|
|
|
560 | (2) |
|
|
|
562 | (1) |
|
|
|
562 | (1) |
|
|
|
563 | (1) |
|
|
|
564 | (11) |
|
|
|
|
|
|
|
|
564 | (1) |
|
|
|
565 | (3) |
|
Hyporeninemic Hypoaldosteronism |
|
|
568 | (1) |
|
Congenital Adrenal Hyperplasia |
|
|
568 | (1) |
|
Syndromes of Adrenocorticoid Hyperfunction |
|
|
569 | (5) |
|
Adrenal Medullary Hyperfunction |
|
|
574 | (1) |
|
Male Reproductive Endocrinology |
|
|
575 | (8) |
|
|
|
|
|
|
|
|
575 | (4) |
|
|
|
579 | (1) |
|
|
|
579 | (1) |
|
|
|
580 | (1) |
|
Benign Prostatic Hyperplasia |
|
|
581 | (1) |
|
Carcinoma of the Prostate |
|
|
581 | (2) |
|
|
|
583 | (16) |
|
|
|
|
|
|
|
|
|
|
|
|
|
583 | (1) |
|
|
|
583 | (2) |
|
|
|
585 | (1) |
|
|
|
586 | (2) |
|
|
|
588 | (6) |
|
|
|
594 | (5) |
|
|
|
599 | (6) |
|
|
|
|
|
|
|
|
599 | (1) |
|
Physiology of Glucose Homeostasis |
|
|
599 | (1) |
|
Clinical Classification of Hypoglycemia |
|
|
600 | (3) |
|
Diagnostic Work-up of Hypoglycemia |
|
|
603 | (1) |
|
|
|
603 | (2) |
| SECTION XII Women's Health |
|
605 | (22) |
|
Women's Health: General Concepts |
|
|
607 | (3) |
|
|
|
|
|
|
|
|
|
|
|
Gender Differences in the Epidemiology of Disease by Age Group |
|
|
607 | (1) |
|
Exercise Across the Feminine Life Cycle |
|
|
608 | (1) |
|
Gender and the Patient-Physician Interaction |
|
|
608 | (2) |
|
Hormonal Influences on Women's Health |
|
|
610 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
610 | (1) |
|
Dysmenorrhea and Premenstrual Syndrome |
|
|
610 | (2) |
|
|
|
612 | (1) |
|
Abnormal Uterine Bleeding |
|
|
613 | (3) |
|
|
|
616 | (1) |
|
|
|
616 | (4) |
|
|
|
620 | (7) |
|
|
|
|
|
|
|
|
|
|
|
|
|
620 | (1) |
|
|
|
621 | (1) |
|
Breast Cancer and Benign Breast Disease |
|
|
622 | (1) |
|
Cancer of the Cervix, Uterus, and Ovary |
|
|
623 | (1) |
|
Sexually Transmitted Diseases and Pelvic Inflammatory Disease |
|
|
623 | (2) |
|
|
|
625 | (1) |
|
|
|
625 | (1) |
|
Disorders of Cognition and Affect |
|
|
626 | (1) |
| SECTION XIII Diseases of Bone and Bone Mineral Metabolism |
|
627 | (40) |
|
Normal Physiology of Bone and Bone Minerals |
|
|
629 | (10) |
|
|
|
|
|
|
Bone Structure and Metabolism |
|
|
629 | (1) |
|
|
|
630 | (2) |
|
|
|
632 | (2) |
|
|
|
634 | (2) |
|
|
|
636 | (1) |
|
|
|
637 | (2) |
|
The Parathyroid Glands, Hypercalcemia, and Hypocalcemia |
|
|
639 | (10) |
|
|
|
|
|
|
|
|
639 | (1) |
|
|
|
640 | (5) |
|
|
|
645 | (4) |
|
|
|
649 | (5) |
|
|
|
|
|
|
|
|
649 | (1) |
|
|
|
649 | (3) |
|
|
|
652 | (1) |
|
Laboratory and Radiographic Features |
|
|
652 | (1) |
|
|
|
652 | (1) |
|
|
|
652 | (2) |
|
|
|
654 | (8) |
|
|
|
|
|
|
|
|
654 | (1) |
|
Etiology and Pathogenesis |
|
|
654 | (2) |
|
|
|
656 | (1) |
|
|
|
656 | (1) |
|
|
|
656 | (2) |
|
|
|
658 | (2) |
|
Glucocorticoid-Induced Bone Loss |
|
|
660 | (2) |
|
|
|
662 | (5) |
|
|
|
|
|
|
|
|
662 | (1) |
|
|
|
662 | (1) |
|
Pathology and Pathophysiology |
|
|
662 | (1) |
|
|
|
662 | (1) |
|
|
|
663 | (1) |
|
|
|
663 | (1) |
|
|
|
663 | (4) |
| SECTION XIV Musculoskeletal and Connective Tissue Disease |
|
667 | (58) |
|
Approach to the Patient with Rheumatic Disease |
|
|
669 | (4) |
|
|
|
|
|
|
Musculoskeletal History and Examination |
|
|
669 | (2) |
|
|
|
671 | (1) |
|
|
|
672 | (1) |
|
|
|
673 | (5) |
|
|
|
|
|
|
Epidemiology and Genetics |
|
|
673 | (1) |
|
|
|
673 | (1) |
|
|
|
673 | (1) |
|
|
|
674 | (1) |
|
|
|
675 | (1) |
|
|
|
675 | (2) |
|
|
|
677 | (1) |
|
|
|
678 | (4) |
|
|
|
|
|
|
|
|
678 | (1) |
|
|
|
678 | (1) |
|
|
|
679 | (1) |
|
|
|
680 | (1) |
|
|
|
681 | (1) |
|
Systemic Lupus Erythematosus |
|
|
682 | (5) |
|
|
|
|
|
|
|
|
682 | (1) |
|
|
|
682 | (1) |
|
|
|
683 | (1) |
|
|
|
684 | (3) |
|
Antiphospholipid Antibody Syndrome |
|
|
687 | (2) |
|
|
|
|
|
|
|
|
687 | (1) |
|
|
|
687 | (1) |
|
|
|
687 | (1) |
|
|
|
688 | (1) |
|
Systemic Sclerosis (Scleroderma) |
|
|
689 | (5) |
|
|
|
|
|
|
Epidemiology and Genetics |
|
|
689 | (1) |
|
Pathology and Pathophysiology |
|
|
689 | (1) |
|
|
|
689 | (2) |
|
Diagnosis and Differential Diagnosis |
|
|
691 | (1) |
|
|
|
691 | (2) |
|
|
|
693 | (1) |
|
Idiopathic Inflammatory Myopathies |
|
|
694 | (4) |
|
|
|
|
|
|
Pathology and Pathophysiology |
|
|
694 | (1) |
|
|
|
694 | (2) |
|
|
|
696 | (1) |
|
|
|
696 | (1) |
|
|
|
696 | (2) |
|
|
|
698 | (3) |
|
|
|
|
|
|
|
|
698 | (1) |
|
|
|
698 | (2) |
|
|
|
700 | (1) |
|
|
|
701 | (6) |
|
|
|
|
|
|
|
|
701 | (1) |
|
|
|
701 | (1) |
|
|
|
702 | (1) |
|
Specific Types of Vasculitis |
|
|
702 | (2) |
|
|
|
704 | (1) |
|
Autontibodies and Vasculitis |
|
|
705 | (1) |
|
|
|
705 | (2) |
|
|
|
707 | (5) |
|
|
|
|
|
|
|
|
707 | (4) |
|
Calcium Pyrophosphate Deposition Disease |
|
|
711 | (1) |
|
|
|
711 | (1) |
|
|
|
712 | (3) |
|
|
|
|
|
|
|
|
712 | (1) |
|
Clinical Features and Diagnosis |
|
|
713 | (1) |
|
|
|
714 | (1) |
|
Nonarticular Soft Tissue Disorders |
|
|
715 | (5) |
|
|
|
|
|
|
Etiology and Pathogenesis |
|
|
715 | (1) |
|
|
|
715 | (1) |
|
Diagnosis of Nonarticular Soft Tissue Disorders |
|
|
716 | (1) |
|
|
|
716 | (1) |
|
|
|
717 | (1) |
|
|
|
717 | (3) |
|
Rheumatic Manifestations of Systemic Disorders |
|
|
720 | (5) |
|
|
|
|
|
|
Rheumatic Syndromes Associated with Malignancy |
|
|
720 | (1) |
|
|
|
721 | (1) |
|
Gastrointestinal Diseases |
|
|
722 | (1) |
|
|
|
723 | (1) |
|
|
|
724 | (1) |
| SECTION XV Infectious Disease |
|
725 | (150) |
|
Organisms That Infect Humans |
|
|
727 | (6) |
|
|
|
|
|
|
|
|
727 | (1) |
|
|
|
727 | (1) |
|
|
|
728 | (1) |
|
|
|
728 | (1) |
|
|
|
728 | (2) |
|
|
|
730 | (1) |
|
|
|
731 | (1) |
|
|
|
732 | (1) |
|
Host Defenses Against Infection |
|
|
733 | (8) |
|
|
|
|
|
|
Local Barriers to Infection |
|
|
733 | (1) |
|
Components of the Immune System |
|
|
734 | (3) |
|
Nonspecific Effector Mechanisms |
|
|
737 | (1) |
|
Resistance to Extracellular Bacteria: Encapsulated Organisms |
|
|
738 | (1) |
|
Resistance to Obligate Intracellular Parasites: Viruses |
|
|
739 | (1) |
|
Resistance to Facultative Intracellular Parasites: Mycobacterium tuberculosis |
|
|
740 | (1) |
|
Laboratory Diagnosis of Infectious Diseases |
|
|
741 | (4) |
|
|
|
|
|
|
Diagnosis by Direct Visualization of the Organism |
|
|
741 | (1) |
|
Diagnosis by Detection of Microbial Antigens |
|
|
742 | (1) |
|
Diagnosis by Examination of Host Immune or Inflammatory Responses |
|
|
742 | (1) |
|
Assays that Detect Microbial Nucleoside Sequences |
|
|
743 | (1) |
|
Diagnosis by Isolation of the Organism in Culture |
|
|
743 | (1) |
|
|
|
744 | (1) |
|
Isolation of Rickettsia, Chlamydia, and Mycoplasma |
|
|
744 | (1) |
|
|
|
744 | (1) |
|
Isolation of Fungi and Mycobacteria |
|
|
744 | (1) |
|
|
|
745 | (5) |
|
|
|
|
|
|
|
|
745 | (1) |
|
|
|
745 | (1) |
|
Characteristics of the Antimicrobial |
|
|
746 | (1) |
|
|
|
746 | (1) |
|
|
|
746 | (3) |
|
|
|
749 | (1) |
|
Monitoring of Antimicrobial Therapy |
|
|
749 | (1) |
|
|
|
749 | (1) |
|
|
|
749 | (1) |
|
Antimicrobial Resistance Testing |
|
|
749 | (1) |
|
Fever and Febrile Syndromes |
|
|
750 | (15) |
|
|
|
|
|
|
Regulation of Body Temperature |
|
|
750 | (1) |
|
|
|
750 | (2) |
|
|
|
752 | (8) |
|
|
|
760 | (3) |
|
Factitious or Self-Induced Fever |
|
|
763 | (2) |
|
|
|
765 | (6) |
|
|
|
|
|
|
|
|
765 | (1) |
|
|
|
766 | (1) |
|
|
|
767 | (2) |
|
|
|
769 | (1) |
|
|
|
769 | (2) |
|
Infections of the Nervous System |
|
|
771 | (11) |
|
|
|
|
|
|
|
|
772 | (6) |
|
|
|
778 | (1) |
|
|
|
779 | (1) |
|
Spectrum of Tuberculous, Fungal, and Parasitic Infections |
|
|
779 | (3) |
|
Infections of the Head and Neck |
|
|
782 | (6) |
|
|
|
|
|
|
|
|
782 | (1) |
|
Infections of the Nose and Sinuses |
|
|
782 | (1) |
|
Infections of the Mouth and Pharynx |
|
|
783 | (5) |
|
Infections of the Lower Respiratory Tract |
|
|
788 | (10) |
|
|
|
|
|
|
|
|
788 | (1) |
|
|
|
789 | (1) |
|
|
|
789 | (1) |
|
|
|
790 | (1) |
|
Specific Pathogenic Organisms |
|
|
791 | (4) |
|
|
|
795 | (1) |
|
|
|
796 | (2) |
|
Infections of the Heart and Vessels |
|
|
798 | (7) |
|
|
|
|
|
|
|
|
798 | (4) |
|
Prosthetic Valve Endocarditis |
|
|
802 | (1) |
|
Prophylaxis of Infective Endocarditis |
|
|
803 | (1) |
|
Bacterial Endarteritis and Suppurative Phlebitis |
|
|
804 | (1) |
|
Skin and Soft Tissue Infections |
|
|
805 | (6) |
|
|
|
|
|
|
Superficial Infections of the Skin |
|
|
805 | (4) |
|
Deeper Infections of the Skin and Soft Tissue |
|
|
809 | (2) |
|
Intra-Abdominal Abscess and Peritonitis |
|
|
811 | (4) |
|
|
|
|
|
|
|
|
811 | (1) |
|
Abscesses of Solid Organs |
|
|
811 | (2) |
|
|
|
813 | (1) |
|
|
|
813 | (2) |
|
|
|
815 | (6) |
|
|
|
|
|
|
Pathogenesis and Pathophysiology: General Concepts |
|
|
815 | (1) |
|
Types of Microbial Diarrheal Diseases |
|
|
815 | (3) |
|
General Epidemiologic Considerations |
|
|
818 | (1) |
|
|
|
818 | (1) |
|
Management: General Principles of Electrolyte Repletion Therapy |
|
|
818 | (3) |
|
Infections Involving Bones and Joints |
|
|
821 | (4) |
|
|
|
|
|
|
|
|
821 | (2) |
|
|
|
823 | (1) |
|
|
|
823 | (2) |
|
Infections of the Urinary Tract |
|
|
825 | (3) |
|
|
|
|
|
|
|
|
825 | (1) |
|
Cystitis and Pyelonephritis |
|
|
825 | (2) |
|
|
|
827 | (1) |
|
|
|
828 | (4) |
|
|
|
|
|
|
|
|
828 | (1) |
|
Approach to the Hospitalized Patient with Possible Nosocomial Infection |
|
|
828 | (1) |
|
|
|
829 | (1) |
|
Intravascular Catheter-Related Infections |
|
|
830 | (1) |
|
|
|
831 | (1) |
|
Nosocomial Urinary Tract Infection |
|
|
831 | (1) |
|
Sexually Transmitted Diseases |
|
|
832 | (9) |
|
|
|
|
|
|
|
|
832 | (4) |
|
Urethritis, Cervicitis, and Pelvic Inflammatory Disease |
|
|
836 | (4) |
|
Proctocolitis in Homosexual Men |
|
|
840 | (1) |
|
HIV Infection and the Acquired Immunodeficiency Syndrome |
|
|
841 | (22) |
|
|
|
|
|
|
|
|
|
|
|
|
|
841 | (2) |
|
|
|
843 | (3) |
|
Diagnosis and Testing for HIV Infection |
|
|
846 | (1) |
|
Sequential Clinical Manifestations of HIV-1 Infection |
|
|
847 | (2) |
|
Management of HIV Infection |
|
|
849 | (3) |
|
Management of Specific Clinical Manifestations of Immunodeficiency: A Problem-Oriented Approach |
|
|
852 | (1) |
|
|
|
853 | (2) |
|
|
|
855 | (3) |
|
|
|
858 | (2) |
|
Gastrointestinal Diseases |
|
|
860 | (1) |
|
|
|
860 | (1) |
|
|
|
861 | (1) |
|
AIDS-Associated Malignancies |
|
|
861 | (1) |
|
Other Complications of HIV Infection |
|
|
861 | (1) |
|
Prevention of HIV Infection |
|
|
862 | (1) |
|
Infections in the Immunocompromised Host |
|
|
863 | (5) |
|
|
|
|
|
|
Disorders of Cell-Mediated Immunity |
|
|
863 | (1) |
|
Disorders of Humoral Immunity |
|
|
864 | (1) |
|
Impaired Neutrophil Function |
|
|
864 | (1) |
|
|
|
865 | (1) |
|
Diagnostic Problems in the Compromised Host |
|
|
865 | (1) |
|
Prevention and Treatment of Infections in the Patient with Neutropenia |
|
|
866 | (2) |
|
Infectious Diseases of Travelers: Protozoal and Helminthic Infections |
|
|
868 | (7) |
|
|
|
|
|
|
|
|
868 | (2) |
|
|
|
870 | (1) |
|
Protozoal and Helminthic Infections |
|
|
871 | (4) |
| SECTION XVI Neurologic Disease |
|
875 | (126) |
|
Neurologic Evaluation of the Patient |
|
|
877 | (6) |
|
|
|
|
|
|
Taking a Neurologic History |
|
|
877 | (1) |
|
The Neurologic Examination |
|
|
878 | (1) |
|
|
|
879 | (4) |
|
Disorders of Consciousness |
|
|
883 | (7) |
|
|
|
|
|
|
|
|
883 | (1) |
|
|
|
884 | (3) |
|
|
|
887 | (1) |
|
|
|
887 | (3) |
|
|
|
890 | (3) |
|
|
|
|
|
|
|
|
890 | (1) |
|
|
|
890 | (1) |
|
|
|
890 | (1) |
|
|
|
891 | (1) |
|
|
|
891 | (1) |
|
|
|
892 | (1) |
|
|
|
893 | (3) |
|
|
|
|
|
|
|
|
893 | (1) |
|
|
|
893 | (3) |
|
Dementia and Memory Disturbances |
|
|
896 | (5) |
|
|
|
|
|
|
|
|
896 | (3) |
|
Other Memory Disturbances |
|
|
899 | (2) |
|
Disorders of Mood and Behavior |
|
|
901 | (5) |
|
|
|
|
|
|
|
|
901 | (1) |
|
Depression and Bipolar Disorders |
|
|
902 | (2) |
|
|
|
904 | (1) |
|
|
|
904 | (1) |
|
|
|
905 | (1) |
|
|
|
905 | (1) |
|
Personality Disorders and Substance Abuse |
|
|
905 | (1) |
|
Disorders of Thermal Regulation |
|
|
906 | (3) |
|
|
|
|
|
|
|
|
906 | (1) |
|
|
|
906 | (3) |
|
Headache, Neck Pain, and Other Painful Disorders |
|
|
909 | (9) |
|
|
|
|
|
|
|
|
909 | (6) |
|
|
|
915 | (3) |
|
Disorders of Vision and Hearing |
|
|
918 | (7) |
|
|
|
|
|
|
Disorders of Vision and Eye Movements |
|
|
918 | (4) |
|
Hearing and Its Impariments |
|
|
922 | (3) |
|
|
|
925 | (4) |
|
|
|
|
|
|
Approach to the Diagnosis |
|
|
925 | (3) |
|
|
|
928 | (1) |
|
Disorders of the Motor System |
|
|
929 | (10) |
|
|
|
|
|
|
Symptoms and Signs of Motor System Disease |
|
|
929 | (1) |
|
Movement Disorders and Ataxia |
|
|
930 | (3) |
|
Hypokinetic Movement Disorders |
|
|
933 | (2) |
|
Hyperkinetic Movement Disorders |
|
|
935 | (2) |
|
|
|
937 | (2) |
|
Developmental and Neurocutaneous Disorders |
|
|
939 | (3) |
|
|
|
|
|
|
|
|
939 | (1) |
|
|
|
939 | (1) |
|
|
|
939 | (1) |
|
|
|
939 | (1) |
|
Malformations of Cortical Development |
|
|
940 | (1) |
|
Developmental and Neurocutaneous Disorders |
|
|
940 | (2) |
|
|
|
942 | (11) |
|
|
|
|
|
|
|
|
942 | (1) |
|
|
|
942 | (1) |
|
|
|
943 | (1) |
|
|
|
943 | (2) |
|
|
|
945 | (2) |
|
|
|
947 | (1) |
|
|
|
947 | (1) |
|
Primary Stroke Prevention |
|
|
947 | (1) |
|
Management of Acute Stroke |
|
|
948 | (1) |
|
|
|
949 | (2) |
|
|
|
951 | (1) |
|
|
|
952 | (1) |
|
|
|
953 | (3) |
|
|
|
|
|
|
|
|
953 | (2) |
|
|
|
955 | (1) |
|
|
|
955 | (1) |
|
|
|
956 | (9) |
|
|
|
|
|
|
|
|
956 | (1) |
|
|
|
956 | (1) |
|
Classification and Clinical Manifestations |
|
|
956 | (4) |
|
|
|
960 | (1) |
|
|
|
961 | (1) |
|
|
|
962 | (2) |
|
|
|
964 | (1) |
|
Discontinuing Antiepileptic Drugs |
|
|
964 | (1) |
|
Central Nervous System Tumors |
|
|
965 | (4) |
|
|
|
|
|
|
|
|
965 | (1) |
|
|
|
965 | (1) |
|
Evaluation of the Patient |
|
|
966 | (1) |
|
|
|
966 | (1) |
|
|
|
967 | (2) |
|
Infectious Diseases of the Nervous System |
|
|
969 | (4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
969 | (1) |
|
|
|
970 | (1) |
|
Malignant External Otitis |
|
|
970 | (1) |
|
|
|
970 | (1) |
|
Septic Cavernous Sinus Thrombosis |
|
|
971 | (1) |
|
|
|
971 | (1) |
|
Septic Sagittal Thrombosis |
|
|
971 | (1) |
|
Neurologic Complications of Infectious Endocarditis |
|
|
971 | (1) |
|
|
|
972 | (1) |
|
Demyelinating and Inflammatory Disorders |
|
|
973 | (6) |
|
|
|
|
|
|
|
|
973 | (2) |
|
|
|
975 | (1) |
|
|
|
975 | (2) |
|
Acute Transverse Myelitis |
|
|
977 | (1) |
|
Acute Disseminated Encephalomyelitis |
|
|
977 | (2) |
|
Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerver Disease |
|
|
979 | (9) |
|
|
|
|
|
|
|
|
980 | (1) |
|
Diseases of the Motor Neuron (Anterior Horn Cell) |
|
|
981 | (1) |
|
|
|
982 | (1) |
|
|
|
982 | (1) |
|
|
|
983 | (1) |
|
|
|
984 | (4) |
|
|
|
988 | (10) |
|
|
|
|
|
|
Organization and Structure of Muscle |
|
|
988 | (1) |
|
|
|
988 | (2) |
|
|
|
990 | (1) |
|
|
|
991 | (1) |
|
|
|
991 | (1) |
|
Specific Mitochondrial Disorders Affecting Muscle |
|
|
992 | (1) |
|
Channelopathies (Nondystrophic Myotonias and Periodic Paralyses) |
|
|
993 | (1) |
|
|
|
994 | (2) |
|
Myopathies Caused by Endocrine and Systemic Disorders |
|
|
996 | (1) |
|
|
|
996 | (1) |
|
|
|
997 | (1) |
|
Neuromuscular Junction Disease |
|
|
998 | (3) |
|
|
|
|
|
|
|
|
998 | (1) |
|
Lambert-Eaton Myasthenic Syndrome |
|
|
999 | (1) |
|
Drug-Induced Myasthenic Syndromes |
|
|
1000 | (1) |
|
Organophosphate Intoxication |
|
|
1000 | (1) |
| SECTION XVII The Aging Patient |
|
1001 | (10) |
|
|
|
1003 | (8) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1003 | (2) |
|
Demographics of Aging and Implications for Health Care |
|
|
1005 | (1) |
|
Assessment of the Older Patient |
|
|
1006 | (1) |
|
Common and Often Inadequately Assessed Medical Problems of the Elderly |
|
|
1006 | (5) |
| SECTION XVIII Substance Abuse |
|
1011 | (12) |
|
Alchol and Substance Abuse |
|
|
1013 | (10) |
|
|
|
|
|
|
|
|
|
|
|
|
|
1014 | (1) |
|
Tobacco and Alcohol Abuse |
|
|
1014 | (4) |
|
|
|
1018 | (2) |
|
|
|
1020 | (3) |
| Appendix Commonly Measured Laboratory Values |
|
1023 | (6) |
| Index |
|
1029 | |
Other versions by this Author
